Agaricus blazei helps enhance T-cell activity

Preliminary Study

Effect of hot water extract from Agaricus blazei Murill on antibody-producing cells in mice

A. Nakajima-a, T. Ishida-a, M. Koga-a, T. Takeuchi-b, O. Mazda-c and M. Takeuchi-a

a- Department of Biotechnology, Faculty of Engineering, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, Japan
b- Department of Hygine, Kagoshima University Faculty of Medicine, Kagoshima, Japan
c- Department of Microbiology, Kyoto Prefectual University of Medicine, Kyoto, Japan

Received 17 May 2002;  revised 17 May 2002;  accepted 19 May 2002.  Available online 17 June 2002.

Abstract

We investigated the immunopotentiating activities of boiled water-soluble extracts from desiccated Agaricus blazei Murill (ABM). Effect of ABM extract on antibody production was investigated by method of hemolytic plaque-forming cells (PFC) against sheep red blood cells (SRBC) antigen. ABM extracts significantly (p<0.01) increased the number of PFC in spleen with intraperitoneal administration at doses of 25 mg/kg as compared with control group. The populations of Mac-1- or CD25-positive cells significantly (p<0.01, p<0.001) increased, but in CD19-positive cells, there were no differences in ABM-treated mice as compared with control mice. The expressions of IL-6 and IL-1β mRNA were augmented by ABM extract in both peritoneal macrophages and spleen cells. These results suggested that ABM extract might be an effective stimulator for T cell and macrophage to IL-1β and IL-6 release, resulting in augmentation of antibody production against SRBC antigen.

Author Keywords: Agaricus blazei Murill; Antibody production; Mice

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